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Looking at the structure inside cells
How complex and structured is the inside of a cell? It's hard to imagine, but the internal organisation of cells is typically precisely controlled by molecular skeletons and scaffolds, giving cells the...
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TrypTag.org
The website for one of my new major research projects is now live!TrypTag.orgTrypTag is a project to tag every gene in the trypanosome genome with a fluorescent marker to see where it goes in the...
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Molecular Cell Biology of Protozoan Parasites - Ghana 2017
Things change fast in Ghana! Three years ago, I helped teach a course for young African scientists in the University of Ghana in Accra. This January I got the chance to do the same again, and it has...
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Moving in a straight line - sounds simple, right?
One hundred years ago Asa Schaeffer blindfolded his friend and challenged him to walk in a straight line. He did three loops of a spiral, before tripping over a tree stump. This wasn't a cruel prank,...
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How to be a parasite
For an organism to become a parasite it has to adapt to live in a host. This might mean it needs to grow faster, invade cells or tissues, or avoid being killed by the immune system. It can also...
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How happy are your HeLa cells?
Figure 1. HeLa cell nucleus happiness scale. HeLa cells expressing FUS eGFP were asked how they felt. The morphology of the nucleus and nucleolus, visible via FUS eGFP localisation, was used to infer...
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How does a cell swim fowards?
“Why are they swimming backwards?” This is one of the most common questions I get asked whenever I show a video of Leishmania parasites swimming.Swimming Leishmania at 200 frames per second (8× slower...
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Tryp/Leish Stickers!
It's been a busy year starting my lab... But in more important news, T. brucei, T. cruzi and Leishmania stickers!
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Trypanosomatid cell structures
These are my oft-requested diagrams of trypanosomatid parasites. They're heavily inspired by the amazing illustrations of trypanosomatids by Keith Vickerman, like this classic, though with a more...
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